Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Euphorbia Genus

Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Euphorbia Genus

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Euphorbia is a large genus of the Euphorbiaceae family.Around 250 species of the Euphorbia genus have been studied chemically and pharmacologically; different compounds have been isolated from these species, especially diterpenes and triterpenes.Several reports show that several species have anti-inflammatory activity, which can be attributed to the presence of diterpenes, such as abietanes, ingenanes, and lathyranes.In 2 Layers Wood Sign addition, it was found that some diterpenes isolated from different Euphorbia species have anti-cancer activity.

In this review, we included compounds isolated from species of the Euphorbia genus with anti-inflammatory or cytotoxic effects published from 2018 to September 2023.The databases used for this review were Science Direct, Scopus, PubMed, Springer, and Google Scholar, using the keywords Euphorbia with anti-inflammatory or cytotoxic activity.In this review, 68 studies were collected and analyzed regarding the anti-inflammatory and anti-cancer activities of 264 compounds obtained from 36 species of the Euphorbia genus.The compounds included in this review are terpenes (95%), of which 68% are diterpenes, especially of the types ASPARAGUS ingenanes, abietanes, and triterpenes (approximately 15%).